This TECDOC was developed by the Nuclear Harmonization and Standardization Initiative Regulatory Track and offers comprehensive approaches for the cooperation of regulatory bodies in the review of advanced reactors and particularly small modular reactors. This report focuses on how regulatory bodies can effectively utilize other regulatory bodies' reviews and how they can work together while independently reviewing a design against national requirements. This document is informed by valuable insights from previous and ongoing multinational regulatory review activities and other international efforts on harmonization. It is an invaluable resource for regulatory bodies, technical support organizations and industry organizations involved in the pre-licensing and licensing of advanced reactors.