1 Introduction
The History of Tissue Sealing and Hemostasis
The General Use of Fibrin Glues and Collagen Sponge
The General Use of the Fixed Combination of Collagen Sponge and Tissue Glue
2 General Remarks
The Fixed Combination of Collagen Sponge and Clotting Factors
Composition of TachoSil®
Product Characteristics
Mode of Action
General Indications in Neurosurgery
Macroscopical and Histological Reaction and Postmortem Findings
Experimental Evaluation of the Structure of the Tissue Glue–Coated Collagen in MRI Scans
3 Special Remarks
The Tissue Glue–Coated Collagen Sponge in Hemostasis and Tissue Sealing
Cranial Applications
Case Reports on the Use of Fleece-Bound Sealing in Cranial Neurosurgery
4 Results
General Remarks
Material-Related Results
Cranial Applications
Spinal Applications
Acceptance and Contentment
5 Summary and Conclusion
