DNA-Encoded Libraries

1 Introduction
2 DNA-Compatible Organic Reactions
2.1 Amide-Bond-Forming Reactions
2.2 Metal-Promoted DEL-Compatible C—C Bond Forming Reactions
2.3 Metal-Free DEL-Compatible C—C Bond Forming Reactions
2.4 On-DNA C—X (X = N, O, P, S, Se) Bond Forming Reactions
2.5 On-DNA C—H Transformations
2.6 On-DNA Photoredox-Catalyzed Reactions
2.7 On-DNA Cyclization Reactions
2.8 DNA-Encoded Isocyanide Multicomponent Reactions
2.9 On-DNA Functional-Group Transformations
2.10 Reversible Immobilization of DNA for Chemical Modification
2.11 Covalent Attachment on a Solid Support
2.12 Micelle-Mediated Synthesis
3 DEL Encoding and Setup Strategies
3.1 DNA-Templated Synthesis
3.2 DNA-Recorded Synthesis
3.2.1 Single Pharmacophore Libraries
3.2.1.1 Encoding Using Double-Stranded DNA: A Headpiece-Based DNA Ligation Strategy
3.2.1.2 Encoding Using Single-Stranded DNA (Iterative Splint-Ligation Procedures)
3.2.1.3 Chemical Ligation/Encoding
3.2.2 Dual-Pharmacophore Libraries
3.2.2.1 Encoded Self-Assembling (Dynamic) Chemical Libraries
3.2.2.2 Peptide Nucleic Acid (PNA) Encoded Libraries
3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries
3.2.3 Special Libraries
3.2.3.1 Macrocyclic DELs
3.2.3.2 Natural-Product-Enriched DELs
4 Library Selection Procedures
4.1 Selections by Affinity Capture on Solid Support
4.2 DEL Selection Using DNA-Programmed Affinity Labelling (DPAL)
4.3 Selections of DNA-Encoded Libraries to Protein Targets on Living Cells
4.4 Selections of DNA-Encoded Libraries to Protein Targets within Living Cells
5 Evaluation/Cheminformatic Methods
5.1 Informatic Tools, Processing, and Evaluation of DEL Selection Data
5.2 On-DNA Resynthesis and Affinity Selection Mass Spectrometry (ASMS)