Contents
Preface
Eric D. Green
List of Abbreviations
Introduction: Complexity, Contingency, and Controversy in Genomics
Christopher R. Donohue and Alan C. Love
Part I. Producing the Genome
1. Challenges in the Early Years of the Human Genome Project at the National Institutes of Health: A Personal Retrospective
Elke Jordan
2. Unsung Contributors to the Human Genome Project: NIH Staff and Advisors
Mark Guyer, Kris A. Wetterstrand, and Jane Peterson
3. The NHGRI Genome Sequencing Cost Curve: An Indicator of Scientific Progress
Kris A. Wetterstrand and Jonathan E. LoTempio Jr.
4. History of the Encyclopedia of DNA Elements (ENCODE) Project
Elise A. Feingold
5. NHGRI Genetic Variation Program
Lisa D. Brooks
6. Genome Technology Development Grants for the Human Genome Project and Beyond
Jeffrey A. Schloss
Part II. Contextualizing the Genome
7. The Nature of Genomic Publishing
Chris Gunter and Magdalena Skipper
8. Europe and the Genome: An Overlooked Strategy for a Translational Genomics
Miguel García‐Sancho
9. Technological Change Driving Scientific Questions: Genomic Sequencing as a Case Study
Adam Felsenfeld and Kris A. Wetterstrand
10. Addressing Ethical, Legal, and Social Implications (ELSI): Navigating Ongoing Productive Tensions
Joy Boyer and Jean McEwen
11. "Variations on a Theme": A History of Errors and Polymorphisms in the Human Genome Project and Beyond
Christopher R. Donohue
12. Transforming the Genome into a Clinical Resource: DNA, Data, and Algorithms in Medicine
Ramya M. Rajagopalan
Part III. Interpreting the Genome
13. The Difference Genomics Makes: Characterizing Human Differences After the Human Genome Project
Rina Bliss
14. The Trouble with Being "Socially Responsible": Science, GWAS, and Sexual Orientation
Michel Dubois, Catherine Guaspare, and Eric Vilain
15. Epigenetics in Public Health: Comments on the "From Cells to Society" Approach
Alexandra Soulier
16. When Eugenic Enhancement Meets the Myth of Genetic Reductionism
Sahotra Sarkar
17. modENCODE and the Elaboration of Functional Genomic Methodology
Stephan Guttinger and Alan C. Love
18. The Cancer Genome Atlas Project: Data-Driven, Hypothesis-Driven, or Something In-Between?
Anya Plutynski
19. Large-Scale Biology: Philosophical, Historical, and Computational Perspectives
Emanuele Ratti and Thomas Stoeger
Contributors
Index